The record linkage methodology by linking government databases may help to address research questions about the path of patients in the care network without spending time and financial resources with primary data collection.
The use of observational studies of databases and registries may help to elucidate the clinical course of this heterogeneic disease and assist in the identification of factors that may be employed to enrich the patient population, and so increase the likelihood of demonstrating a treatment effect with the available therapeutic options.
A forensic DNA database may help criminal investigators to establish links between a particular suspect of a specific crime and other unsolved crimes, or can provide support to identify potential suspects while clearing other suspects in the early stages of an investigation (Cutter 2006; Kaye 2006).
Here, the new cREMaG (cis-Regulatory Elements in the Mammalian Genome) database is presented, which may help to resolve the above problems and allow for the discovery of TFs responsible for the regulation of co-expressed genes.
Last but not least, the complete database may help mass spectrometry services to identify the great proportion of unknown peptides in their data sets which cannot be currently matched to any protein in existing databases.
The high-throughput capability of next-generation sequencing technologies offer the opportunity to generate large transcriptome databases relatively rapidly, which may help to speed up the tedious, often de novo [ 20], assignment of proteomic-gathered data.
Integration with other genomic resources including PACdb (28), a database for cell-based pharmacogenomics, may help to better elucidate the mechanisms underlying genetic variants implicated in drug response traits, which have been widely investigated using this model.
User testing of this database is anticipated in the future and may help to clarify areas of confusion or ambiguity.
These mutations may help to enrich the GALC pathogenic mutation database and increase public awareness of Krabbe disease in Morocco.
These data, if valid, may help to expand the coverage of administrative databases to include more minor injuries, capturing care delivered in physicians' offices and emergency departments.
