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In The Netherlands all prescriptions are registered in an administrative database, including date of prescription, number of prescribed tablets, prescriber and dosage regimen.
For each patient, medical records were collected in the NHI claim database, including date of admission, date of discharge, dates of visits, clinical diagnosis, prescription and total expenditure.
Notifications from June 2003 to December 2008 were retrieved from the Dutch national database, including date of symptom onset, date of laboratory-confirmed diagnosis, and date of reporting to the Municipal Health Service (MHS).
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Data obtained from the Canadian mortality database included date of death and underlying cause of death.
Information available in the Ontario database includes dates of onset of illness, patient's age and sex, and city and hospital or healthcare facility from which specimens were submitted (13 ).
The Registered Persons Database consists of demographic information, including date of death for all Ontario residents.
This database includes dates and types of offences in criminal cases heard by local, district and supreme courts of NSW, and dates of receptions to and discharges from the custody of Corrective Services NSW.
Doctors' services were identified using the Ontario Health Insurance Plan database, and we obtained basic demographic information, including date of death, from the Registered Persons database.
(Additional file 1) The Ontario Registered Persons Database contained basic demographic information for each eligible individual including date of death.
The AUICC database contains data on all ICU admissions during the study period, including date of ICU admission and discharge, use of mechanical ventilation, and renal replacement therapy.
Personal factors including date of birth and gender of the young adult with Down syndrome are ascertained from the database.
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