Furthermore, in retrospective studies based on data retrieved from large databases, inaccuracies and, therefore, underestimations due to incompleteness of data cannot be excluded.
As the design of the primers and probes for gene expression measurement is usually based on the gene sequence information from the RefSeq and non-RefSeq databases, any inaccuracies in those databases or the presence of previously unknown SNPs or splice variants, will potentially affect the accuracy of the assays.
Data within claims databases may have inaccuracies introduced through coding errors that could not be identified because of a lack of access to additional patient records.
The latter sequence could not be confirmed independently, but sequence differences between the other eight FL sequences from barley and the assembly1-morex rcba, suggest Hv- Clo11 derived from the viroblast high through-put database may contain some inaccuracies.
To maximize the number of one-to-one matches between the databases, extensive efforts were made to correct inconsistencies and inaccuracies in both databases, such as name misspellings and incorrect dates of birth.
Another limitation due to the use of administrative databases is the inaccuracy in differentiating etiologies of diseases and the reporting of organ dysfunction, engendering confusion bias.
Such changes can lead to confusion and inaccuracies in the database.
We find the inaccuracies in the database were primarily due to the design of the logbook, which permits the trainee to add and remove fields in the various data collecting categories.
A further limitation of HES, common to administrative databases, is the potential for inaccuracies and omissions in coding.
First, in spite of information accuracy and completeness required by administrative databases for payment purposes, billing inaccuracies and missing data may still occur.
Second, as with all claims databases, the NIS may contain inaccuracies or omissions in coded diagnoses/procedures, leading to the potential for misclassification bias.
