This analysis was based on the database used for the primary outcome of the sequential treatments at median follow-up of 71 months [ 12].
The database lock for the primary efficacy analysis took place on 15 November 2010 after 75 investigator-assessed PFS events had taken place in the two treatment arms combined, as pre-specified in the statistical analysis plan of the study.
The eventual nominee is highlighted in yellow, candidates who never formally entered the campaign are in blue, and the right-most column of each chart shows the number of polls each candidate was included in as a fraction of the total number of polls in our database for that primary cycle).
24 31 Secondary outcomes included a number of other key adverse maternal and perinatal outcomes that were derived using the same databases as for the primary outcomes.
The database was locked for the primary unblinded analysis after study day 90, and the study continued in a single-blinded fashion, although individual study allocations were not disclosed to on-site study investigators or staff with the exception of the principal investigator.
The database was locked for the primary unblinded analysis after study day 90 so that results could be used to plan a Phase 2 trial, and the study continued in a single-blinded fashion, although individual study allocations were not disclosed to on-site study investigators or staff, with the exception of the principal investigator.
Data were unblinded for statistical analyses after the data were screened for accuracy and completeness, protocol violators were identified, and the databases were locked for the primary analysis at month 36 (Villa et al, 2005).
Local alignments to the National Centre for Biotechnology Information (NCBI) non-redundant (nr) and plant protein databases were generated for the primary assembled transcripts from the tr2aacds pipeline using uBLAST (Edgar RC, unpublished) [ 29].
In addition to being a resource of information about compounds, this database is the primary repository for High Throughput Screening results generated by the Molecular Libraries Screening Centers Network (MLSCN) [4], part of the NIH Roadmap.
We used the HUGO Gene Nomenclature Committee (HGNC) database as the primary source for naming canonical genes.
