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The lack of a community sampling frame (i.e. TPV holders were not represented on any publicly accessibly database) constrained the sampling strategy for the survey.
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The HOGs used in Bgee are part of the database schema, are constrained according to the database optimization, and are not formatted for easy external use.
High quality spectra may show unidentified peptides in a typical data analysis due to several reasons like smaller number of peptides generated due to improper digestion of protein, inaccurate charge state or precursor ion m/ z measurement, constrained database search parameters, presence of chemical or posttranslational modifications, and incompleteness of the protein sequence database [ 27].
Assuming that the accountprofile database table is constrained to stay on-premise, in a symmetric partitioning algorithm separating getAccountData from doAccount (7 ~ KB of data exchange) is preferred over cutting executeQuery (13 ~ KB of data exchange).
The database searches were constrained by allowing for trypsin cleavage (with up to two missed cleavage sites), fixed modifications (carbamidomethylation of Cys residues) and variable modifications (oxidation of Met residues and N-terminal pyroglutamate formation).
One could perhaps dismiss this innovation as a simpler version of an already simple model, though it may possess advantages when applied within constrained databases.
Currently, database searching efficiency is constrained by the size of the database, the method used to determine similarity and the function defining match quality.
The database architecture is designed to scale well even with very large quantities of data; database size is primarily constrained by available hard drive space.
Enhanced understanding of how sampling techniques affect estimates of the global U Pb age-distribution have, in turn, constrained U Pb database design.
The query tool accesses the central database through a highly constrained "click and point" interface.
The line between documents will feel artificial much like a database view merely constrains the output.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com