The details of the databases considered in the experiments are discussed under separate subheadings as a convenience.
Figure 6 shows a few examples of the pairs of face images of the AT&T and generic FRGC databases considered in the experiments.
The Supplementary Materials site provides downloadable files containing signatures for all gene isoforms in the four databases considered in this study.
The value of 65 years, chosen as reference age, was considered to be representative of the average age of the patient seen in clinical practice; in particular it coincides with the average age of the patients included in the work of Dickson et al., where the clinical relevance of the six databases considered in this study is explored [8].
Furthermore, from the structural database considered in current study, Cu-TDPAT with strong CO2 adsorption sites was found to possess the best performance by taking the thermal and water-stable properties into account.
The 15 secondary databases considered in this study could therefore be reduced to three gene-related information sources that are relevant across multiple cancer types with regard to the considered class of models.
Table 1 shows all databases considered in this research.
While the overall quality of HAPPI is comparable to that of the HPRD database, HAPPI PPIs with 3-5 staranknk levels have a higher average quality than all other human PPI databases considered in this study, which include ProNet, UniHI, IntNetDB, OPHID, HPRD, and BioGrid.
MGEx-Tdb performed better, than other databases considered, in predicting the expression status of genes, when queried with various physiological conditions (see table 4, also see additional file 9 for methods).
The self-healing aspect of a self-managing database was considered in the reference [55].
Several high-fidelity experimental datasets from the TNF workshop database are considered in the present work to demonstrate the effectiveness of the proposed methodologies.
