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The estimates were calculated by calibrating the predicted breast cancer incidence rates to the actual rates from the Surveillance, Epidemiology, and End Results (SEER) database and the predicted distributions of screen-detected tumor sizes to the actual distributions obtained from the Breast Cancer Surveillance Consortium (BCSC).
A computational tool for the evaluation of a correlation between the functional annotations in the SWISSPROT database and the predicted intrinsic disorder was elaborated [ 48- 50].
The recall rate of the domain-based method (36.6%) is significantly lower than that of the GOA database method (47.5%) since the InterPro database used for the domain-based method is only one of information sources to build the GOA database and the predicted GO terms are often less than the annotations in GOA database.
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The predicted motifs are ranked and validated with known motifs in other databases, and the predicted motif modules are validated with known TF interactions to facilitate further research.
There was good agreement between smoking prevalence based on medical records in the THIN database and those predicted by GHS: 22.4% compared to 21.8% respectively in men; 18.9% compared to 20.2% respectively in women.
Information from the literature was used to close gaps in the metabolic pathways, include pathways specific to A. baylyi that were unknown to the metabolic databases, and check the predicted pathways, for instance for the specificity of the cofactors.
A subsequent run of MAKER was performed using Genemark and Augustus with the Uniref50 protein database [ 33] and the predicted proteins from A. flavus AF70 and A. parasiticus as evidence of protein homology.
False discovery analysis for OFFGEL samples, calculated as less than 1% for reported proteins, was conducted using Mayu [ 53] and searches against a database comprising the predicted protein set from the Oases assembly and the reverse of each sequence (Additional file 9).
To understand more deeply the structure-function relationship of the epitopes, the 3-D structure of GAD500 585 was modeled and optimized based on the crystal structure of GAD from the PDB database (PDB code: 2okk) and the predicted secondary structure of GAD500 585 (data not shown), as shown in Figure 7a.
Ryu et al. [ 10] collected 33,651 protein-sequence variations from the SwissVariant database and predicted the effects of variants on phosphorylation binding sites using a phosphorylation-related variant prediction tool.
We initially searched the genome of the non-jawed vertebrate P. marinus and the predicted proteome databases for BbZP protein homologues to elucidate how the ZP proteins of the basal chordates are evolutionarily related to those of vertebrates.
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