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Patient age at study inclusion was independently associated with hospital mortality in our results, which confirm previous observations [27, 28] and is supportive of the validity of the database and the analysis performed.
Each list was annotated in categories of biological processes according to the Gene Ontology database and the analysis was performed in WebGestalt [ 28].
Data were entered in duplicate into a Microsoft Access (Seattle, Washington) database and the analysis was performed using SPSS (release 19.0 SPSS Inc. Chicago, Illinois, USA).
Illumina ID of differential expressed genes was uploaded to the DAVID database and the analysis was performed using the algorithm within the softwares.
The melanin biosynthesis pathway was not listed in the KEGG database, and the analysis was conducted alternatively with the following steps: First, we used UCSC mouse genome database mm5 and the Gene Ontology database [ 29] to identify all the melanin biosynthesis related genes.
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The method defines an efficient data interface between the clinical/administrative databases and the analysis datasets [ 61, 62].
CGG design the study, prepared the database and conduct the analysis.
JS collected HCV data from public database and performed the analysis.
We would like to thank all researchers from the Consortium Protocol 3 who work on the database and on the analysis of implementation of projects.
The total number of unigenes that produced hits and the number of different motifs identified varied highly depending on the database size and the analysis method.
Moreover, researchers can vary the genomic database and the pathway analysis program.
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