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A search in the databanks has shown that many mammalian peptides could also be substrates of this and/or the Bombina enzyme.
The enzyme has a rather broad specificity, particularly with respect to the amino acid in position 2. A search in the databanks has shown that many potential substrates for such an isomerase are present in the skin secretions of other frogs as well as in mammalian cells.
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Other studies have shown similar frequency, Adzhubei and co-workers in a recent review (11) estimated about 2% of residues in Protein Databank to be in PPII-helices of length 3 and more residues.
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