The conclusion is that the SHAR data cannot with certainty be used as an estimation of the total infection burden after THR.
This, and when possible the insertion of stable isotopes at key locations in the cell, should enable the interpretation of whole-cell Raman data with increasing certainty.
If the data for the side of the operation are unavailable, then it is not possible to compare left-side with right-side THR from the registry data with any certainty.
As previously discussed, it should be borne in mind that part of the algorithm's philosophy is to reject such irregular waveforms and report them as 'invalid' to avoid false alarms due to motion artefact or the transmission of data with low certainty of accuracy.
As the referees have pointed out correctly, it is one thing to show that Hop1 is a conditional regulator of Red1 deposition (this can be derived from the ChIP-seq data with high certainty), but a more sophisticated problem to compare two ChIP-seq profiles and scale them correctly, relative to each other.
The same situation is faced in haplotype-based analyses (Schaid et al., 2002) and association tests in imputed data (Lin et al., 2008; Marchini et al., 2007), in which we do not know the underlying data of interest with certainty but do know the how to model the probability distribution of these data.
"One thing the data tells us with certainty: There are many children and families who need help," Dr. Thomas R. Frieden, director of the C.D.C., said in a news conference on Thursday.
While we don't know what Luter will do in his post, there is enough data to predict with certainty how African Americans will vote in this 2012 election, as it was predicted in 2008, irrespective of the president's views on marriage equality or right-wing anti-gay agendas.
Since we wish to represent each spatial point on the painting with depth data with a high certainty, an approach like passive (entirely non-invasive) stereo vision is not optimal.
