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Simulated data were then created by sampling data points { x 1, …, x n i } at site C i with corresponding { Meth 1, …, Meth n i } sampled with probability p (Meth j = methylated ) = L i new, where n i is the coverage at location C i. Pseudocode for creating simulated data is shown in Section 5 of the Supplementary Data.

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A 1-port source model with parameters derived from the in-duct data was then created.

Data display tables were then created to facilitate the examination of similarities and differences across respondents to identify key themes.

Genes identified as being regulated by F/R, or by deletion of either C/EBPδ or C/EBPβ, are listed in Supplementary Data Set 2. Custom scripts were then created to compare the list of known genes closest to ChIP peaks with gene lists generated from RNA microarray experiments (Supplementary Data Set 1).

The data files representing the differentially expressed genes were then created.

Proportionate Venn diagrams were then created based on these data sets.

Binary image masks were then created using an automatic threshold to create an image including all fluorescence data above background.

Quintiles of socioeconomic status were then created.

Second level codes were then created.

An analytic data set was then created by deleting all subjects with any incomplete responses; this dataset thus contains only subjects with complete information whereby the true score was known for all subjects.

A data file was then created that indicated, for each course within each year, the presence of a statistically significant gender difference, the magnitude of the difference, the subject area/content and the format of the exam questions as indicated above.

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