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The data were reconstructed with different reconstruction methods.

Patient and normal data were reconstructed with iterative reconstruction with correction for attenuation, scatter and septal penetration (ACSC), the same reconstruction without corrections (IRNC), and filtered back-projection (FBP) with data quantified using small volume-of-interest (VOI) (BRASS) and large VOI (Southampton) analysis methods.

Volumetric data were reconstructed with segmented reconstruction.

Volumetric data were reconstructed with half or segmented reconstruction.

Therefore, all data were reconstructed with FBP using the same reconstruction protocol.

PET data were reconstructed with an OSEM algorithm and PSF reconstruction, analysed blindly and validated by a pathologist who measured the largest nodal metastasis per axilla.

Both Type 1 and Type 2 artifacts can be effectively eliminated when the k-space energy-anchored EPI data are reconstructed with the recently developed multischeme partial-Fourier reconstruction algorithm, as shown in the bottom row.

Received data are reconstructed with MSE ~5·10-6.

μPET data was reconstructed with two-dimensional ordered subsets expectation maximization (OSEM2D) [ 40] algorithm using four subsets and 16 iterations following Fourier rebinning (FORE) [ 41].

PET data were reconstructed iteratively with the ordered-subsets expectation maximization 3D algorithm.

After the acquisition, the data were reconstructed iteratively with the HiSPECT software (Bioscan Inc).