Τhe unpaired t-tests for the statistical analysis of our data were performed using GraphPad Prism 6.
Functional annotations of the variants called in the WGS data were performed using ANNOVAR (version 2015Dec14) and RefSeq.
Comparisons between two independent groups of numerical data were performed using the non-parametric Mann Whitney test.
Statistical analyses that compared two groups of data were performed using the Student's t test, with a P value of <0.05 taken to indicate a statistically significant difference.
Quantitative data were obtained using Agilent Feature Extraction software (Agilent Technologies) and corrections for background signal intensity for the data were performed using a method, previously described45.
Numerical and statistical analyses of data were performed using Excel 2010 (Microsoft, Redmond, WA) and Graph-Pad Prism 6 (Graph Pad Software La Jolla, CA).
Pre-processing and GLM analyses of the localizer fMRI data were performed using statistical parametric mapping software (SPM12; http://www.fil.ion.ucl.ac.uk/spm/) implemented in MATLAB.
Statistical analysis and graphing of data were performed using SPSS ver. 24.0 (IBM Corp).
Between-group comparisons of non-parametric data were performed using the Mann-Whitney U test.
All analyses regarding behavioral data were performed using SPSS (Statistical Program for Social Sciences; Version 22.0).
Reduction and analysis of all XAS data were performed using IFEFFIT/SIXPACK [53].
