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Quantitative data included prevalence estimates which were extracted as reported in each study and then standardized to percentages to facilitate comparisons between studies.
Volumes and mean FA were extracted, as reported here.
Data were extracted as they were reported in the original paper or based on the answers of the authors to our queries.
When one publication reported more than one cohort, data were extracted as separate studies.
If the results from a single study were reported in more than one publication, data were extracted as one study.
Data were extracted as intention to treat analyses where all dropouts are assumed to be treatment failures, whenever this was allowed by trial reporting.
Data were extracted as a modified intention-to-treat analysis.
Raw data were extracted as pair files using NimbleScan software.
Data were extracted as intention-to-treat analyses, i.e. all withdrawals and dropouts were assumed to be treatment failures, if trial reporting provided relevant information.
Placental RNA was extracted as reported [5], [9].
RNA was extracted as reported before [ 18].
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