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The correlations of the experimental data were completed using the Wilson-HOC, NRTL-HOC and UNIQUAC-HOC models.
The data were completed using metabolic databases - mainly Metacyc [ 24], KEGG [ 22] -.
For repeated measures, missing data were completed using the last observation carried forward (LOCF) method.
Missing data were completed using information from the redundant markers of the contiguous assembly.
In those patients with missing values, data were completed using multiple imputation methods.
All simulations and model analyses were performed using NONMEM 7.1.2 facilitated with PsN 3.3.2 [ 9, 10], and statistical analyses of the data were completed using R 2.14.1 (http://www.r-project.org).org
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Final analysis of the DICOM data was completed using Dolphin 3D (version 10.5, Dolphin Imaging, Chatsworth, CA, USA).
Analysis of the fMRI data was completed using statistical parametric mapping (SPM5; http://www.fil.ion.ucl.ac.uk/spm).ac.uk/spm
Hierarchical clustering of protein data was completed using average linkage clustering, and visualized using Cluster and TreeView software, respectively (http://rana.lbl.gov/EisenSoftware.htm).htm
Statistical analysis of final data was completed using SPSS 19.0.
Network analysis of the microarray data was completed using the Ingenuity Pathway Analysis software [ 50].
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