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Patients without respective data were assigned as non-responders.
Hospital episodes where comorbidities that were documented in the medical charts but were not coded in the hospital administrative data were assigned as under-reporting.
Hospital episodes where comorbidities that were not documented in the medical charts but were coded in the hospital administrative data were assigned as over-reporting.
The genes in TAQ data were assigned as up-regulated gene if the average expression level of sample B is larger than that of sample A, and labeled as down-regulated gene if the average expression level of sample A is larger than that of sample B. 70%and90%90 % confidence level were used to carry out the lists of DEG by DAR method.
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It is a sample by sample process where the first cycle data is assigned as the reference cycle data, and computation starts from the second cycle.
Cox proportional hazards regression was used to estimate the average age- and sex-adjusted relevance of each baseline characteristic to the risks of ESRD and death (the small numbers of participants with missing data were assigned the mean or median value, as appropriate).
Boys aged 6 18 years, term-born, inhabiting a region of the same urbanization level as the examined boys with ADHD, without endocrine diseases, whose parents had answered 'no' to the above questions, and for whom complete data were collected, were assigned as the control group.
Due to lack of data, four children per family were assigned as maximum.
Genotypic data (mostly Single Nucleotide Polymorphism) were assigned as described in Atwell et al. [ 35] and are publically available at the AtPolyDB database (https://easygwas.tuebingen.mpg.de/data/public/dataset/view/1/).
Medical doctors who care for patients were assigned as data collectors at each private institution and were supervised by the investigators.
Six experienced diploma nurses were used as data collectors and two bachelor nurses were assigned as supervisors for the quantitative portion of the study.
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