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Using mathematical principles, a genetic – epidemiological probability function was derived that links binary disease data to the underlying epidemiological traits, host susceptibility and infectiousness.
The first stage of the model contains two likelihood terms representing the probabilistic relationships of the PM2.5 and AOD data to the underlying processes and covariates.
In the future, registration algorithms might improve matching of the 3DcinePC velocity data to the underlying morphological data and further reduction in the potential for this type of error.
Usually, NMR-based GWAS either use a selection of chemical shifts or perform spectral annotation to reduce the NMR data to the underlying metabolite concentrations (for example, [ 6, 7, 17]).
Another limitation comes with the use of explicit emission models, such as Poisson and Binomial distributions, to connect noisy data to the underlying genomic states (see Supplemental Experimental Procedures).
We assessed the goodness of fit of our empirical data to the underlying path model by evaluating the chi-squared significance.
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A computational model was developed to integrate these disparate data to reveal the underlying pathways and mechanisms involved in saturated fatty acid toxicity.
The extracted principal components are then analyzed in conjunction with marker data to map the underlying loci.
A recent research trend consists of exploiting the topological properties of protein-protein interaction (PPI) networks combined with other biological data to envisage the underlying mechanisms of genetic diseases.
This is so even in the absence of data, due to the underlying relationship between measures.
IN contributed data to the MONIKA database underlying this methodological investigation and critically revised this manuscript draft by bringing in ophthalmological expertise.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com