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The first-layer BLSOM was constructed with each of the divided input data pieces that represents the data subclass, such as phylotype division, resulting in compression of the number of data pieces.
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OpenBabel stores these data in subclasses of OBGenericData such as OBPairData (for the data fields in molecule files such as MOL files and SDF files) and OBUnitCell (for the data fields in CIF files).
In line with our previous results [ 15], we chose in this study, to divide the data between subclasses belonging to coherent physiological situations (weeks of pregnancy, influence of the placenta).
The HMMER approach gave better results for the catalase family as each profile specifically recruits each subclass (data not shown).
Antibody subclass data confirmed this dichotomy, with alum promoting an IgG1-dominated antibody response associated with Th2 induction, and CpG adjuvants boosting only IgG2a responses that are dependent on Th1-derived IFNγ (16, 19).
Newton-Cross et al. [ 11] matched the most important habitat types for predicting main sett presence and absence with 1 km square habitat subclass data from the CEH Land Cover Map 2000, and calculated the probability of badger presence for each 1-km square.
FcγRIIIa was negative in binding of all IgG subclasses (data not shown).
There was no statistically significant difference in the survival curves among these subclasses (data not shown).
This assumption gives the possibility to reduce data, define disease subclasses and eventually identify pathways [ 32].
The SC-BLSOM achieves higher speed by dividing input data into phylogenetic subclasses and structuring BLSOMs in a hierarchical manner.
However, there are insufficient quantitative data on the subclasses of death to be certain: deaths are relatively few and difficult to classify reliably by cause.
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