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Existing schedulers assume that the underlying architecture is homogeneous, and as consequence, they may not be well suited for AMP and NUMA systems, since they, respectively, do not properly explore hardware elements asymmetry, while improving memory utilization by avoid multi-processes data starvation.
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We need to systematically address missing data values, outlier detection, feature subset selection and the continuous evolution of predictions as the project unfolds, and all of this in the context of data-starvation and noisy data.
Author reply: In order to make clear how the body weight is affected by energy intake, we chose the data of starvation period from the Minnesota human starvation study.
No additional filtering criteria were applied for the WT and vps4∆ data under starvation conditions.
We agree with this and have intensively studied the literature and found a number of relevant links of our metabolite data to starvation and senescence.
The similarities found here between the three microarrays data (carbon starvation, exponential x stationary phase, and cspC mutant x wild type at stationary phase) strongly suggests that cspC has an important role in nutrient starvation response at this phase.
The reviewer also asked about analysis of the histidine starvation data in the Lareau paper as another positive control, and we analyzed these data and give the result in the text.
The proposed detection method uses the Hellinger distance between two probability distributions generated from training and testing data to detect starvation.
Gasch et al. [26] reported amino acid starvation data, where transcription of Met4 regulated genes was induced.
No significant increase in SGK1 expression levels was found when the cells were treated with serum over a period of 5 days, after serum starvation (data not shown).
It was observed that glucose was utilized and biofilms formed on the PE before any significant planktonic growth was detectable (Figure 3B), and that the total cellular-protein content of the biofilms on PE always contributed >60% relative to total cellular protein content of the whole culture before starvation (data not shown).
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