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Our data propose that the anti-inflammatory properties of dasatinib in pre-clinical models may be explained, at least in part, by the inhibition of the SIKs.
Our data propose that the embryonic expression pattern of miR-21 is maintained or re-established during initiation and progression of glioblastoma.
Our data propose that the diabetic state caused significant structural changes in the glomerular basement membrane and podocytes, resulting in proteinuria.
Previous data propose that the serine 727 phosphorylation is important for the effect of STAT3 on mitochondrial respiratory complex 1 and 2 activities [ 27, 44].
Therefore, our data propose that the pattern formation of BMPs and TGF- βs which subsequently determine skeletal patterning depends on the oscillatory secretion of the morphogens themselves which is mediated by metabolic oscillations.
These data propose that the ratio of mutant ubiquitin (UBB+1) to wild-type ubiquitin (encoded by UBI4) is more relevant for determining UBB+1-triggered cytotoxicity than the proteasomal capacity.
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Although a previous hypothesis on the geographic origin of parthenogenesis in Artemia, based on allozyme data, proposed that the parthenogenetic lineage appeared in the Mediterranean Basin between 3 and 6 Myr ago [25], coinciding with the Messinian salinity crisis (around 6 My ago [32]), more recent data challenge this hypothesis.
Therefore, it was rather surprising when molecular data proposed that the evolutionary history of these birds dated back to the end of the Cretaceous [ 1, 2].
Together, the results of these experiments support the hypothesis derived from the GSEA-analyzed human microarray data proposing that the activation of the downstream mediators of GF signaling contributes to tamoxifen resistance in ER+ BC.
These early data proposed that the major structural protein is RebB and that RebA may act as a scaffold to facilitate the polymerization process whereas RebC may act as a transcriptional regulator (Heruth et al. 1994).
In the 70's, Horman and Viani [ 5, 6], on the basis of NMR chemical shift data, proposed that the caffeine-chlorogenate complex might be described as a 1 1 type π-molecular complex stabilized by hydrophobic interations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com