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This survey on a large cohort of 2,313 headache sufferers in the general population provides important data on tolerance and safety of tSNS with the Cefaly® device as well as some information about its performance.
Indeed, data on tolerance and outcome in these patients remain lacking.
In addition, this study will provide valuable data on tolerance and safety of this therapy as well as data on compliance and health economics.
Since some recent European studies have reported a frequent use of sufentanil in preterm neonates [ 16, 17] or a trend to increasing its use [ 18], we consider that data on tolerance and safety are necessary.
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New empirical data on conditioned tolerance are needed to evaluate the proposed theory, and the design for an evaluation is suggested here.
Phase I and II studies have a critical role in designing comparative clinical trials of antifungal therapy by providing data on safety, tolerance, and plasma pharmacokinetics of the investigational agent.
Routine hemodynamic and pulse oximetry data, and qualitative data on patient tolerance were collected before, during, and after HFCWO.
Our data on thermal tolerance of H. hampei on the other hand would predict that the pest is well capable to thrive also under sub-tropical conditions.
Moreover, data on thermal tolerance of an insect is crucial to predict the possible effects of climate change [e.g.], [57], [21], [22], [58].
Calculated data on warming tolerance and thermal safety margins of H. hampei for the three East African locations showed considerably high variability compared to the Colombian site.
Calculated data on warming tolerance (WT) and thermal safety margins (TSM) of the insect for the three East African locations showed considerably high variability compared to the Colombian site (Table S2).
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