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Objectives: To provide data on mechanisms of selective drug action and features of drug resistance that may be clinically important.
Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I, DeMarini DM, Caldwell JC, Kavlock RJ, Lambert P, Hecht SS, Bucher JR, Stewart BW, Baan R, Cogliano VJ, Straif K (2015) Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis.
27– 32 Several recent studies also provided new data on mechanisms of sports-related injuries.
Furthermore, our study failed to produce conclusive data on mechanisms and severity of possible blood-brain barrier injury.
Although direct inhibitors of mTOR kinase activity are being developed, most data on mechanisms of resistance apply to rapamycins.
In the present review, we summarize data on mechanisms, diagnosis, outcomes, prognostic markers and treatment options for RC in HF.
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Information on hazardous properties, including data on mechanism and toxicokinetics, is necessary to define the critical endpoints and the relevant parameters to assess internal exposure and its relation to external exposure.
The amount of data on mechanism of action and chronic toxicity for DEET to aquatic environment is still limited.
A major issue with the study at its present stage is the relatively weak data on mechanism, particularly with regards to the potential role of AMPK in this system.
Reviewer #1: This manuscript by Zhao provides data on mechanism by which Ngn1 prevents Stat1/3 phosphorylation, thus inhibiting astrogenesis during a primarily neurogenic stage of development using primarily in vitro approaches.
We also included data on the mechanisms behind induction of pluripotency, as long as the mechanisms were concerned with the gain of pluripotency, and not the loss of lineage-specific traits.
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