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Information on hazardous properties, including data on mechanism and toxicokinetics, is necessary to define the critical endpoints and the relevant parameters to assess internal exposure and its relation to external exposure.
The amount of data on mechanism of action and chronic toxicity for DEET to aquatic environment is still limited.
Reviewer #1: This manuscript by Zhao provides data on mechanism by which Ngn1 prevents Stat1/3 phosphorylation, thus inhibiting astrogenesis during a primarily neurogenic stage of development using primarily in vitro approaches.
A major issue with the study at its present stage is the relatively weak data on mechanism, particularly with regards to the potential role of AMPK in this system.
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Objectives: To provide data on mechanisms of selective drug action and features of drug resistance that may be clinically important.
27– 32 Several recent studies also provided new data on mechanisms of sports-related injuries.
Furthermore, our study failed to produce conclusive data on mechanisms and severity of possible blood-brain barrier injury.
Although direct inhibitors of mTOR kinase activity are being developed, most data on mechanisms of resistance apply to rapamycins.
In the present review, we summarize data on mechanisms, diagnosis, outcomes, prognostic markers and treatment options for RC in HF.
Experimentally evolved lineages of bacteria have provided important data on mechanisms involved in short-term bacterial evolution and adaptation [ 1- 3] in simple controlled environments.
In describing and discussing our data on these issues, we contribute to the relatively small body of empirical data on mechanisms to strengthen community involvement in peripheral health facilities in low and middle income countries [ 3, 4, 11].
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