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DATA AND METHODS:We used the Framingham Heart Study data on life span and on individual genetic background to construct two sets of PCs.
In C. elegans, the available data on life span extension is controversial.
Data on life span and weekly mortality were analysed in WinQTLCart/QTL Cartographer [ 45, 46], using composite interval mapping.
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There are data on effect of the drugs on life span in worms, mice and rats.
The second is the fact that the two procedures: (i) selection of longevity SNPs and (ii) testing the presence of their joint influence on life span used data on the same individuals.
The available data on effect of antidiabetic biguanides on life span in mice and rats are summarized in the Table 1.
There are only few data on the effect of other than biguanides antidiabetic drugs on life span of animals.
Moreover, there are no available data on effect of natural light/dark regimen at circumpolar region on life span and tumorigenesis in rodents.
Data on individuals from the first 309 families plus data on 162 individuals with missing family identities were used for selecting SNPs having effect on life span.
If the procedures, described above, do select longevity variants, and if the detected pattern of joint influence of such variants on life span is a property of a biological mechanism, then genetic variants selected using data on one population should be able to predict life spans in other genetically independent population of individuals who experienced similar environmental and living conditions.
The over-expression of HSP42 had no effect on the lifespan (data not shown), suggesting that the wild-type levels of Hsp42 are sufficient to provide its maximal effects on life span, which is consistent with the appearance of the deposit early in life span in the wild-type cells.
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CEO of Professional Science Editing for Scientists @ prosciediting.com