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International organizations need to keep better data on acts of violence against humanitarian workers, including rape.
With 5 10 years of programmatic use, emerging artemisinin-tolerant falciparum malaria in southeast Asia, and the first calls to consider an increased dose of artemisinins, we review neuroauditory safety data on ACTs to treat uncomplicated falciparum malaria.
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Despite the limited data on ACT, the small published studies consistently confirm an impressive clinical response rate of up to 50% in metastatic melanoma patients, including a significant proportion of patients with durable complete response.
During the introduction of RDTs, the definition of 'malaria-like fever' was formalized to improve targeting of RDTs (Figure 1) and a vetting process put in place to verify accuracy of reporting and collation of health information system data related to malaria, including consumption data on ACT and RDTs.
Four studies included data on ACT use after subsidization in experimental groups compared with unsubsidized controls.
Nine programmatic subsidies implemented prior to the AMFm were identified; however, only three subsidies included data on ACT use.
The ACTwatch Group collected comparable data on ACT use in Madagascar, Nigeria and Uganda, with surveys conducted 1 2 years before implementation of the subsidy and again after almost 2 years of subsidization in Nigeria and Madagascar and ∼1 year in Uganda (ACTwatch Group and ABMS/Benin et al. 2012).
Ten years after this debate, we present an update of the published literature on available safety data of ACTs regarding neuro-ototoxicity when treating uncomplicated malaria and identify remaining knowledge gaps.
Last year, Trasande addressed this scientific disinformation campaign in an article calling on scientists to speak up more forcefully when policymakers do not act on data concluding that chemicals and pesticides pose risks to kids.
However, the costs of collecting more detailed recall data on sex acts and gel use from all CAPRISA 004 trial participants was prohibitive.
Reviews of validity and reliability of HIV research show that sexual behavior data are fairly consistent and self-reported data on sexual acts are reasonably congruent, especially for short recall periods.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com