The data included admission and outcome data, severity of illness scores, physiological measurements, and laboratory values.
Data collected on admission included: demographic data, severity of illness as estimated by the Pediatric Risk of Mortality (PRISM) III score [ 27], organ dysfunction as estimated by the Pediatric Logistic Organ Dysfunction PELODD) score [ 28] and the MODS score [ 29].
We recorded basic demographic data, severity of illness scores, and clinical information, including source of infection and development of organ failure until ICU discharge.
We also collected clinically relevant data from the medical records and phone interviews, including demographic data, duration of illness and CBZ use, dosage and plasma concentration, concomitant medications, and reported side effects.
Demographic data, severity of illness based on sequential organ failure assessment (SOFA), degree of independence (Barthel index) and comorbidities (Charlson Index) were documented.
Demographic data, severity of illness, risk factors for colistin-resistance (described in previous studies), clinical management and hospital outcome of all cases were recorded.
The following information was extracted from the patients' medical record: pre- and post-intubation vital signs, pre- and post-NIPPV and intubation blood gas data, severity of illness (simplified acute physiology score (SAPS II) and acute physiology and chronic health evaluation (APACHE II and IV)) at the time of intubation, and outcomes data including ventilator days and ICU mortality.
Growth parameters, breastfeeding, day-care attendance, immunization data, episodes of illness and medication used were registered for the participants at each visit, as well as medical histories for all household members.
Demographic data, history of illness, and results of clinical examination and laboratory studies were recorded on a standard collection form.
One hundred consecutive patients were evaluated according to their demographic data, severity of illness on admission, incidence of DCI, outcome and choice of treatment.
