An important limitation of the present study is the high proportion of missing data on dose and timing of DES exposure (67% of exposed).
No data on dose, duration of treatment or reason of prescribing were collected.
The current study reports the first prospective toxicity data of dose-escalated IMRT to 78 Gy in combination with rectal separation by a PEG-based medical device, and evaluates feasibility and acute toxicity.
When in 2004 it was decided to provide the radiologists with an additional dosimeter, the AMC had already substantial data of doses monitored on both sides of the lead apron.
Data on doses of PPI were available in 96 of the 99 children with successful pH-monitoring and was at a mean of 1.6 mg/kg (SD ±0.6).
In case of incomplete data for dose or type of oestrogen or progestogen, authors were approached for extra information.
Additionally, the data of surface dose, critical organs doses, and registration were analyzed too.
The model is verified using kinetic data effects of dose response of several antioxidants collected from the bibliography.
A major limitation of VAERS is the lack of denominator data (number of doses of administered vaccine), an element necessary for calculating reporting rates.
Before escalation to the next dose level, safety and PK data of the previous dose level were reviewed by a safety review committee.
We did not see any signs from registry-data of major dose escalations over time among patients who received prescriptions for potent opioid analgesics after tibial shaft fractures.
