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All but one patient with renal cancer treated with E7080 had received at least one prior therapy (Supplementary Data, Table 2, data not documented for one patient), although six of these had not received prior antiangiogenesis therapy.
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However, the quality of the tare data is not documented or even questioned.
Some patients' data were not documented, and it was difficult to trace patients after they were sent home.
Several limitations of our study have to be mentioned: First, we were not able to correct for concomitant steroid medication, as this data were not documented.
Also, concepts are documented in claims data that are not documented in EHRs, and vice versa.
This is a conscious restriction of our study as the reported trial data do not document additional risk factors or the baseline myopathy risk in the general population.
In addition to the expected challenges of converting accounting to economic costs, we encountered another practical limitation of project accounts data not commonly documented in the literature.
These features have all previously been reported in the sheep asthma model [ 24, 28], and together with findings from our present study on cytokine data not previously documented for any other large animal model of asthma, strongly implicates a role for Th2 cytokines in the inflammatory and disease processes in this model system.
Since the data stream of the data replication mechanism is typically not documented for many closed-source DBMSs and might change between releases, the information is not decoded but the whole stream is simply split into blocks of a pre-defined length.
Finally, the template allows some data fields to be left blank when a data variable is unknown or not documented.
Required data may be missing for different reasons: a data point was observed but not documented [ 12] or it was never observed in the first place, either because the observation was not clinically necessary or because it could not be performed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com