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Although comprehensive, there is a possibility that both DBTSS and GEO data might be biased to certain biological niches.
However, they pointed out that the predictions based on their data might be biased owing to a likely overestimation of ORs because of enrichment for familial T2DM and exclusion of individuals with impaired glucose tolerance or impaired fasting glucose.
Data might be biased due to varying qualifications of the raters.
As associations between psychosocial work and self-reported data might be biased by participants' systematic positive or negative response tendencies [ 42, 43] we adjusted for negative affectivity in additional analyses (not shown in the Tables).
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Data collection might be biased by this knowledge.
The data from Mongolians might be biased due to the rather small sample size in this study.
It was a retrospective analysis of data coming from a local registry; data obtained from registries might be biased towards under-reporting, because the report of stroke cases was left to physicians who had to fill a prespecified form and send it back to the Kyoto Medical Association; moreover, this modality of data collection may have introduced a selection bias, lack of logistical data.
For mutation data from cancer patients, we mainly utilized the data from TCGA, which might be biased by sequencing depth, platform, and sample size.
Surprisingly, the frequency of copy number in our cohort of 184 European-descendent subjects was very different than the one in the DGV, which suggests that the data available in this database might be biased due to less reliable measurement techniques.
However, a comparison of ChIP-Seq data with randomly sampled genomic sequences might be biased towards measuring similarities introduced by the technology, such as similar GC content.
To avoid the complexities of peak-calling algorithms that might be biased for differing data types, we used an unbiased approach of centering the data on CTCF motifs that were found within DNase I sites and therefore most likely bound by CTCF.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com