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Furthermore, the pathway analysis of our RNA seq data (Ingenuity) also revealed that AhR and Nrf2 pathways are listed in top 25 (Supplementary Fig. 1).
Consistent with the KEGG data, Ingenuity Pathway Analysis also detected overrepresentation of members of the integrin signaling pathway, which overlaps extensively with the ephrin signaling pathway.
Our global proteomics modeling data, Ingenuity Pathway analysis, and mRNA-protein correlation data further suggested a direct role of Meq and NF-κB in MD transformation.
Many array analysis applications incorporate array derived network data that are valuable aids in characterising the expression profile data (Ingenuity Pathways Analysis (IPA) (Ingenuity® Systems, http://www.ingenuity.com); GeneGo (GeneGo, Inc., St . Joseph MI)).
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To identify signaling and metabolic pathways enriched in specific data sets, Ingenuity Pathway Analysis software core analysis (Ingenuity systems) was utilized to determine the statistical significance of enrichment for the pathways within a given data set.
To characterize the functional consequences of gene expression changes associated with PT treatment and influenza infection, we performed pathway analysis of the gene expression data with Ingenuity Pathways Analysis.
The sub networks derived from the proteomic data using Ingenuity Pathway Analysis have many common proteins connected with the important hubs such as AR, c-Myc, ERS1, Akt/PKB and their role in PCa progression or potential as disease markers is not known yet (Figure 6A D).
We also subjected these microarray data to Ingenuity pathway analysis (Additional file 4: Figure S4).
Evaluation of the iTRAQ data by ingenuity pathway analysis identified apo A1, A2, B, C3, E and J (Clusterin) to contribute in the top-rated network (Fig. 2).
Additional file 5: Gene lists from data curated Ingenuity Pathway (TP53 Canonical Pathway) were compared to prediction and functional ranking of p53 REs.
In addition, we also consulted commercially curated pathway data from Ingenuity (Redwood City, CA, USA), GeneGo (Encinitas, CA, USA), NetPro Molecular Connections (Singapore) and Jubilant (Berkley Heights, NJ, USA).
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