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The main reasons are the difficulty of cumulative impact identification caused by lack of data, inability to measure the intensity and spatial effect of all types of impacts and the uncertainty of their future evolution.
This creates challenges to the employer, which include: lack of transparency, inability to analyze data, inability to lower travel expenses systematically and so on.
In addition, lack of a central catalogue for research data, inability to host sensitive data on public servers, and privacy and security concerns make it hard to locate existing data leading to redundancy in research and ambiguity in resources used.
Representativeness and generalization of the results to the entire MSM population in Norway might not be feasible, as Internet sampling is subject to selection bias, misrepresentation as a member of the sampled population, repeated participation, missing data, inability to gather biological specimens etc. [ 9].
Case-based population-level surveillance and cross-sectional serologic surveys to estimate incidence and patterns of influenza infection are limited by the lack of accurate denominator data, inability to account for subclinical infections, difficulties in distinguishing between antibodies induced by natural infection and vaccination, and use of samples from high-risk groups.
Other hurdles considered moderate included time to analyze and interpret data; inability to prospectively validate safety markers; specialized applications, such as identifying idiosyncratic drug reactions; lack of acceptance of approach by senior management within companies; and concerns of litigation from retrospective analysis.
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Furthermore, criminological theories themselves are relatively poor in explaining the crime phenomenon and its control mechanism due to the limitations of its data and inability to experiment with variety of variables [18].
These results agree with our previously published data showing inability of primate inducible Hsp70 to confer yeast viability [40], and indicate that stress-inducible Hsp70s may be partly or totally unable to perform important house-keeping functions that require more efficient activities possessed by the constitutive isoforms.
Since these analyses are based on overall trends in data this inability to discriminate is not surprising.
We were limited by lack of access to clinical data and inability to adjust for clinical variables not captured in administrative health data, such as disease severity.
However, the limitations were lack of corroboration of findings with quantitative data and inability to explore a few contentious findings where consensus couldn't be reached.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com