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"I have concerns not just about patient safety, but the integrity of the data in the trials," she said.
They'll be including that data in the trials for MDD.
We count the number of operations, N ops, that are needed to recover all the data in the trials.
There will be missing data in the trials that we included.
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10 *One trial was excluded because of lack of data in the trial reports.
The choice of 10 replications was prompted by the large amount of missing QoL data in the trial (60%).
7, 8 For telaprevir, these data were not made available to us; however, we were able to utilize the discontinuation data in the trial publications.
Other key outcome data in the trial would be collected from cancer registry data, for example, date of diagnosis and stage.
The disagreement depended on the reporting of data in the trial reports and on how much room was left for decision in the review protocols.
The analysis plan should clearly be pre-specified at the design stage, but in addition methods to prevent or minimize missing data in the trial should be stated.
On the positive side, we did not find any discrepancies between the data in the trial registration and in published papers concerning primary outcome measures.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com