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10 *One trial was excluded because of lack of data in the trial reports.
The choice of 10 replications was prompted by the large amount of missing QoL data in the trial (60%).
The analysis plan should clearly be pre-specified at the design stage, but in addition methods to prevent or minimize missing data in the trial should be stated.
The disagreement depended on the reporting of data in the trial reports and on how much room was left for decision in the review protocols.
7, 8 For telaprevir, these data were not made available to us; however, we were able to utilize the discontinuation data in the trial publications.
On the positive side, we did not find any discrepancies between the data in the trial registration and in published papers concerning primary outcome measures.
Similar(47)
"I have concerns not just about patient safety, but the integrity of the data in the trials," she said.
We count the number of operations, N ops, that are needed to recover all the data in the trials.
There will be missing data in the trials that we included.
SigmaPlot will be used to analyse the data in this trial.
Our economic evaluation was a cost utility analysis, using data collected in the trial, as well as administrative utilization and cost data [ 45].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com