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All comparisons of exercise-based cardiac rehabilitation versus usual care are expressed as relative risks (RRs) with 95% confidence intervals (CI) which were calculated from reported event and population data in each trial.
This was done to ensure at least 50 seconds of data in each trial to examine the time course of activity (i.e. is brain activity in region X sustained for as long as participants are interpreting the gestures?).
The baseline of raw NIRS data in each trial was corrected by linear fitting procedure based on the two baseline data: the mean across a 10-s-period just before the morphing movies, and the mean across a final 10-s period of 40 s after the noise image (Fig. 2).
The aim of the analysis is to partition the variation in the sugar release data in each trial into known sources of genetic and non-genetic variation.
As with other meta-analyses, given the lack of data in each trial, we did not adjust our analysis for adherence to therapy.
Furthermore, we evaluate that spatial adjustment of the phenotypic data in each trial is very important to reduce error in the model and increase prediction accuracy.
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We will aim to obtain all neonatal and maternal morbidity outcome data collected in each trial and not just those reported in publications.
We will report the percentage of observations with missing data in each included trial.
This removed less than 0.4% of the data in each group (G3: 24 trials; G5: 9 trials; Adults: 1 trial).
A population standard deviation of 1 (σ = 1) for the outcome data was assumed in each trial and these data were normally distributed at baseline and at follow-up.
For frequency analysis, the stimulus artefact was removed using a S pike script (A rtrem v.2) with no more than 10 ms of data removed from each trial in data recorded with the Nexstim system, whereas longer-duration artefacts recorded with the D360 system (cases 1, 3, 4, 5 and 7) required up to 80 ms of data to be removed from each trial.
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