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The method integrates miRNA and gene expression profiles in a framework of multiple non-negative matrix factorization, and simultaneously integrates networked data in a regularized manner.
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The miRNA and gene expression profiles are jointly analyzed in a multiple non-negative matrix factorization framework, and additional network data are simultaneously integrated in a regularized manner.
Kernel canonical correlation analysis (KCCA) uses kernels (similarity matrices between objects, here genes) for each type of data to conduct a regularized canonical correlation analysis [5].
For example, Zhang et al. proposed an effective data integration framework using a multiple nonnegative matrix factorization framework and simultaneously integrated additional network in a regularized manner to identify microRNA-gene regulatory modules associated with ovarian cancer [ 12, 13].
Both sides feel it can no longer be treated in a regularized manner".
Through an indirect patterning technique, we generated PAA gels with fluorescent 1 μm dot markers in a regularized array.
Therefore, any method that results in a regularized interface suffices.
The other exemplar (083M02), is dominated by herbs, consisting of agricultural lands in a regularized pattern.
The finite mixtures of LAMs are estimated in a regularized way with a penalized regression spline as smooth for time.
These regulators and their corresponding posterior probabilities of activity are used in a regularized regression framework to predict response.
In particular, we impose a constraint on model parameters in a regularized LR to avoid overfitting and to improve the prediction performance on unseen instances.
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