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Although these data highlighted the potential of molecular research to understand dormancy in this crop, they were insufficient to elucidate the molecular regulation mechanism.
Epidemiologic data highlighted the potential for prevention of colon cancer [ 51, 54], but refining this understanding required repeated measures and intermediate endpoints.
While our previous data highlighted the potential for antiprogestogens for breast cancer prevention, the current data additionally support a clinical breast cancer prevention trial using denosumab to compensate for the low OPG levels throughout the menstrual cycle in BRCA-mutation carriers.
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The data highlighted the inhibitory potential of ME targeted on PTP1B as anti-T2DM drug discovery.
Interesting recent pre-clinical data have highlighted the potential importance of measuring the concentration of circulating tumour cells, which depend critically on tumour circulation for intravasation, as potential biomarkers of VEGF inhibitors (Ebos et al, 2009; Paez-Ribes et al, 2009; Reynolds et al, 2009).
Whilst these data have highlighted the potential usefulness of Raman spectroscopy in stem cell phenotyping, to date repeated measurements of the same cell population in long term culture have been precluded due to the need to maintain sterility, yet the ability to deliver this would be greatly advantageous when developing cell-based regenerative therapies.
Thus, DCE-MRI perhaps holds the greatest promise as a prognostic and/or predictive biomarker for VEGF inhibitors, and recent data have highlighted the potential of another DCE-MRI-derived parameter, vp (the fractional plasma volume), as a further candidate biomarker that may show clinical utility in trials of VEGF inhibitors (Hahn et al, 2008).
Additionally, preliminary data highlights the potential of utilizing embryonic stem cell derived corneal endothelial cells.
These data highlight the potential of ergopeptine alkaloids to affect reproduction through altered endocrine function.
These data highlight the potential of synthetic matrices to steer stem and progenitor cell behavior via defined mechano-adhesive properties.
Combined, these data highlight the potential effectiveness of marine tidal inundation as a landscape-scale acid sulfate soil remediation strategy.
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