However, linkage data and candidate gene approach have not yielded a second PJS gene (Buchet-Poyau et al, 2002).
However, due to the relative low interaction affinity, multiple steps involved in the binding process (conformational changes in AP1 and subsequent binding), and the poor solution behavior of the interactions components (such as μ1 CTD), our repeated attempts have not yielded reliable data.
Unfortunately, as the reviewers anticipated, this goal has not been attainable; our attempts to solidify the link between modification of BiP and translocation attenuation have not yielded consistent compelling data.
Other trials have not yielded such promising results or the data obtained was inconclusive and did not warrant changes in guideline recommendations.
Initial attempts to mutate individual serines in MEG-1 and MEG-3 have not yielded detectable phenotypes, suggesting that the serines may function cumulatively (data not shown).
But these investments have not yielded inclusive outcomes.
However, other ground-based observations have not yielded conclusive evidence.
Yet decades of "back-channel diplomacy" have not yielded results.
Even the most rigorous clone-by-clone sequencing approach has not yielded data on the complete DNA sequences of a centromere from any higher plant or animal species, which have often abundant satellite DNA extending over several hundreds of thousands or millions of base pairs.
8, 9 Research in the field grew as the percentage of women infected with HIV increased, especially in Sub-Saharan Africa, where 67% of the HIV-infected individuals worldwide live. 1 Unfortunately, over the past decade, research into various microbicides has not yielded compelling data for their efficacy.
