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So far, pre-clinical data has established the potential of these inhibitors in tumours that have lost PTEN and became dependent on PI3Kβ [14] 14].
Examination of the previously published preparation and structural assignment of 4a by additional NMR and X-ray crystallographic data has established that nucleophilic addition to the intermediate 2β-methanesulfonyloxymethyl-3β- 4-fluorophenyl tropane unexpectedly provided the aza-bicyclo[3.2β-methanesulfonyloxymethyl-3β- 4-fluorophenyl tropane
Taken together, our data has established that Berberine chloride exerts its leishmanicidal activity both directly, by inducing an oxidative burst in parasites [10] and indirectly, via an increase in IL-12 through enhanced phosphorylation of p38 MAPK.
Prospective placebo controlled data has established the superiority of haloperidol over benzodiazepines (Breitbart et al 1996).
Epidemiological data has established that physical inactivity increases the risk of many chronic diseases including atherosclerosis [ 1- 3].
A large body of data has established a link between cholesterol homeostasis, apolipoprotein E polymorphism and APP processing (Ref. 122).
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Despite infrequent inactivation in many cancers, mutation and functional data have established that KDM6A is a bona fide tumor suppressor gene.
Previous genetic and biochemical data have established a helical switching model for the maturation of the 5′ end of the 17S rRNA (Dammel and Noller, 1993; Young and Steitz, 1978).
Physical (magnetic susceptibility, molar conductance), spectral (IR, 1H NMR, 13C NMR, mass and electronic) and analytical data have established the structures of these synthesized Schiff bases and their oxovanadium(IV) complexes.
Our data have established two empirical findings.
Accumulating data have established that PHD2 is a direct HIF-1α target gene [40], [41].
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