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We go over several statistical challenges raised by this curse occurring in each step of microarray analysis on patient data, from the hypothesis and the experimental design to the analysis methods, interpretation of results and clinical utility.
vitamin K are given in Table 4-wrap>, those based on the total data are in the top half and those following the exclusion of data from the hypothesis generating Bristol study in the bottom half.
This shift did not occur in all studies, and when data from the hypothesis generating Bristol study were excluded, the adjusted odds ratios for leukaemia became 1.06 (0.89–1.25) in the first analysis and 1.16 (0.97–1.39) when data on prophylaxis imputed from hospital policy and perinatal morbidity were used.
This shift did not occur in all studies, and when data from the hypothesis generating Bristol study (Golding et al, 1992) were excluded, the adjusted odds ratios for leukaemia became 1.06 (0.89–1.25) when the analysis was based on evidence from medical notes and 1.16 (0.97–1.39) when data on prophylaxis imputed from hospital policy and perinatal morbidity were added.
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On the other hand, when they excluded the WOSCOPS data from the hypothesis-testing meta-analysis, an approach favored by some (8), a small increase in diabetes risk was found (1.13 [1.13– 1.13]).
Our results combined with data from the literature support the hypothesis of preferential packaging as a common property of rearranged RNA segments to explain the selection of r-RV over wt-RV.
However, data from the literature support the hypothesis that Rhipicephalus spp. ticks are a vector for this rickettsia on the Iberian Peninsula, and our findings confirm that this rickettsia species is circulating in Spain, where specific vectors have yet to be described.
Conversely, both the Fc gamma RIIIa 158 valine/valine and the Fc gamma RIIa 131 histidine/histidine genotypes were found to be independently associated with the response rate and freedom from progression.These data support the hypothesis that ADCC plays an important role in the clinical effect of rituximab at the level of the effector cell.
As a whole, these data support the hypothesis that from a metabolic point of view centenarians are younger than their chronological age.
In addition we compared the predicted responses from the mixture data under the hypothesis of additivity (following the methods in Gennings et al. 2002) to the observed sample means using an F-test (df = 6, 1,305).
We used this restricted model to predict the mean responses for the mixture data using the constraint of additivity given in Equation 1. Finally, we compared the predicted responses from the mixture data under the hypothesis of additivity (Casey et al. 2004; Gennings et al. 2002) with the observed sample means using an F-test.
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