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YT and YH will independently extract data from selected trials using a specially designed data extraction form.
Data from selected trials suggest that, for TGC to exert its clinical benefit, BG values must be maintained in the range of 4.4 to 6.1 mmol/L [ 4, 5].
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Data will be extracted from selected trials included in MAs based on a number of methodological and non-methodological characteristics.
From selected trials, the following data were extracted: name of the first author, year of publication, country(ies) where the study was conducted, number of participants, description of disease evaluated according to groups of global burden of disease and type of funding.
Two reviewers (LTM, ABL) independently extracted the data from all selected trials.
We (SR, CR and SDF) extracted data from the selected trials and independently recorded outcomes.
After collecting data from the selected trials, we correlated the percentage of patients treated with both PBC and EGFR-TKIs with the reported OS, using a weighted analysis.
One author (BCK) extracted data from all trials and the other author (TPM) extracted data from 20 randomly selected trials to assess agreement between authors.
We obtained accrual data for the selected trials by contacting the trial's principle investigator.
We then automatically downloaded all data referring to the selected trials from ClinicalTrials.gov.gov
Three review authors (RIE, DA, and JC) independently extracted data on methods, types of participants, interventions, and outcomes from the selected trials using a standardized data extraction form.
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