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Much of the data from screening these compounds, however, is not efficiently utilized to define structure activity relationships (SAR).
The study is based on routine data from screening units and population registries.
Supporting Information Figure S7 illustrates raw data from screening two 384-well plates containing the same set of compounds.
In addition, the CTU will send each study site 'source data worksheets', to be printed by the study sites and used to record all patient data, from screening through to the end of the trial.
The U.S. Tox21 program has responded to this challenge by proposing alternative strategies for toxicity testing, among which the quantitative high-throughput screening (qHTS) paradigm has been adopted as the primary tool for generating data from screening large chemical libraries using a wide spectrum of assays.
Data from screening women for peripheral parasitemia at first ANC visit with mRDTs at government health facilities shows a similar low prevalence of 0.2% among 19,724 women in 2011 and 27,186 women in 2012, 22, 23 confirming the low risk of MIP in Zanzibar.
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The expected mortality gain as a result of screening was estimated by combining published survival data from screened and unscreened cohorts with routinely published national mortality figures.
Contemporary data derived from screening programmes have been used to define more optimal/individualised screening intervals [ 8– 14, 22, 23].
mRNA expression data obtained from screening analyses were confirmed by separate qRT-PCR analyses performed in triplicate.
The qualitative data from screen captures and semi-structured interviews were analyzed initially to obtain a general sense of data as per six-step approach in analyzing and interpreting qualitative data (Creswell 2002, pp. 237).
In addition to browsing different datasets within a project, data from screens within the same project can be compared using the hit list generation tools.
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