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If it's hard to apply the findings from any one trial to the treatment of a particular patient, it's harder still to use data from many trials to create guidelines that can be applied to any patient.
Given the absence of generic PBM data from many trials, existing mapping algorithms could be more fully utilised as an additional means of deriving HSUVs for economic evaluation of CRC, and also exploratory studies to derive HSUVs for colorectal cancer health states from EORTC QLQ-C30 data using the EORTC-8D or QLU-C10D are warranted.
Collapsing data from many trials in this way permits the use of the present algorithm to improve the accuracy of data even in experimental procedures that elicit only two or three fixations per trial.
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The conclusion that Avandia causes heart attacks and other cardiac issues came from combining data from many different clinical trials, a method that's less powerful statistically than individual trials designed to answer such questions.
Unfortunately, the data from many of the trials reviewed here was limited and severity scores were not used uniformly, therefore this was difficult to assess.
Johnson & Johnson announced an unusual partnership today with Yale University, in which it will share raw data from many of its clinical trials.
Also limiting is the lack of important data from many of the included trials.
This methodology has the advantage of being able to combine data from many small under-powered trials, consideration of the individual results from which might have led to negative or positive conclusions [ 3].
First, they combine data from many sources.
Data from many programs, in fact, find the opposite.
We get our data from many sources.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com