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The usefulness of ortholog identification in several downstream genomic, molecular and evolutionary analyses, coupled with the abundance of genomic data from diverse organisms, has spurred the development of several ortholog prediction algorithms [8].
Although a handful of data support the oxidative damage theory of aging, recent data from diverse organisms put the correlation between oxidative stress and aging into question [ 54].
However, genomic and transcriptomic data from diverse organisms have shown that some eukaryotic lineages lack EF-1α, and these lineages instead were found to possess a putative EF-1α-related GTPase [ 4].
DNA sequence data from diverse organisms have shown that synonymous codons for any amino acid are not used with equal frequency, even though choices among codons should be equivalent in terms of protein sequences [ 1- 6].
However, the availability of the whole genome sequence data from diverse organisms, have allowed scientists to infer the proto-karyotypes of not only the teleost ancestor but also the ancestor to all vertebrates [ 3, 11- 15].
With the rapidly growing collection of sequence data from diverse organisms, homologs for a certain region of interest can be utilized, together with their inherent pattern of evolutionary variation.
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The analysis of another protein complex highlights the necessity of an integrative approach that combines different data sets from diverse organisms: The eukaryotic initiation factor 3 (eis3) is among the largest translation initiation factors in eukaryotes [ 31].
Recently, a database, UbiProt, which contains the information about ubiquitinated substrates from diverse organisms, has been appeared [ 1].
F1000Research: Dataset 1. Mass spectrometry data of purified proteins, 10.5256/f1000research.5873.d39884 Expanding genome sequence data has led to the discovery of a plethora of hemoglobins from diverse organisms through bioinformatics analysis of signature sequences.
Saringosterol (7) has been isolated from diverse organisms, in particular brown algae (for examples see Ref. [42, 43, 50, 51, 52, 53, 54]).
From a total of 428 sequences from diverse organisms none of them showed significant expression levels.
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