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For example, while Hinds et al. performed GWAS to identify allergy-related loci in a sample of personal genetics company customers and birth cohort participants [ 9], they then identified expression quantitative trait loci (eQTL) among these loci using monocyte gene expression data from a distinct study cohort of heart disease.
However a similar parametric analysis of data from a distinct microarray platform also results in the identification of a set of differentially expressed genes that dissimilar to a degree that is beyond what would be expected from false-positive errors alone.
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In response to comments from Reviewers 1 and 3 and the editors, we have now included novel experimental data from a genetically distinct system validating our theoretical results and supporting the quantitative predictions that our work makes.
To bolster the results of our brain RNA-Seq data set, we set out to replicate the main findings of our initial analysis in an independent RNA-Seq data set generated from a distinct tissue source.
The current analysis, which incorporates data from two distinct studies, provides a more comprehensive view of the safety of LAIV in young children with asthma or a history of wheezing.
NEON was conceived in 2000 by former NSF Director Rita Colwell as a novel way to collect massive amounts of data from 20 distinct ecological domains that span a range of terrestrial and aquatic systems.
These data suggested that a distinct mechanism from the transcriptional activation of Sirt1 by nutritional stress, under the control of FoxO3a, was involved in the regulation of Sirt1 by stretch.
We analyzed a time-series of chemically speciated PM measurements in Atlanta, Georgia, and conducted an epidemiologic analysis using data from three distinct source-apportionment methods.
If resetting has occurred, larger inclusions may give higher temperatures, homogenization temperature distributions may show a high-temperature tail, and data from paragenetically distinct settings may overlap.
This progression of qualitative behavior is indeed seen in fig. 3, which shows data from eight distinct concentrations of Lac repressor, as well as a single-operator control in which the DNA lacks a secondary operator.
However, six of the 92 isolates from the existing data set represented a distinct member of the A3b sublineage.
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