These data suggest fragility of the nuclear envelope is specific for the lack of Lamin C. Given that several laminopathies are muscular dystrophies, we investigated the structure of larval body wall muscle in Lamin C nulls.
Until now, it was possible to refer to US, UK, Australian and Swedish data concerning fragility fractures other than those occurring at the hip [ 31- 34].
Mathematical equations can be fit to vulnerability and fragility data using statistical data fitting techniques, such as least squares or maximum likelihood estimation; see Baker (2014), Rossetto et al. (2014b), Lallemant et al. (2015), Tarbotton et al. (2015) and references therein for discussion and review of statistical data fitting techniques.
Recent U.S. jobs data show the fragility of the recovery there.
Thus, there is an urgent need for more accurate fragility data.
In the case where few fragility data are available, the joint distribution of uncertainty of fragility parameters is developed using the likelihood density function method.
Such a model allows for any kinds of marginal distributions and dependence structures so that it can be applied to various types of fragility data, analytical or empirical.
Dataset are often combined to obtain sufficient data to derive fragility functions; care is required to do this appropriately as there will be different biases, sources and magnitudes of uncertainty amongst datasets (Calvi et al. 2006); this discrepancy can influence the quality of the resulting function(s).
FFP's fragility data is available from 2005 to 2014, while IHME's country-level DAH estimates are available from 1990 to 2011.
The epidemiology of osteoporotic fractures in Spain is only partially known: several authors have studied and reported the age, sex and geographical distribution of hip fracture [ 4- 6] and its costs [ 7] using hospital discharge data, but other fragility fractures which do not usually require hospitalization have been poorly described, due to the lack of reliable data.
