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If reliable biokinetic data for the substances are available, the program enables calculations of absorbed dose and effective dose up to 1252 radionuclides published in ICRP Publication 107.
As the spectral and retention time data for the substances in the individual datasets were processed independently with different collision energies and ionization modes, none of the overlapping substances were removed from the datasets.
The toxicological data for the substances were analysed on the basis of reviews, supplemented by original literature, and summarised and evaluated with respect to the exposure data (for details cf. Hahn et al. [ 16]).
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EFSA scientists based their conclusions on the data submitted for the substances' initial market approval, as well as later laboratory and field studies.
The toxicological data for these substances were compiled in substance dossiers.
In the absence of headspace analysis data for the prioritised substances, exposure to vapours was not included for the inhalation route.
Spectra data for the investigated substances are shown below: (I) 1H NMR (600 MHz. DMSO) δ 7.24 (d. J = 3.7 Hz. 1H. fur).
Furthermore, the toxicity data for the individual substances and the mixtures in those studies were derived within the same experimental setting, i.e., presumably with identical test species tested in the same laboratory according to identical test protocols.
Table 7 shows the data for the four substances mentioned above plus the top match based on fragmentation data alone, N-butyl-6-chloro-N (^{prime } -ethyl-1,3,5-triazine-2,4-diamine (CSID 4954587, given the synonym "nButylazine" hereafter to save space).
Secondly, the toxicity data for the single substances can be deemed rather conservative, as (i) exact values were used in case of censored data (e.g. 100 mg/l in case of EC50 > 100 mg/l), (ii) the lowest value was used in case of a toxicity range (e.g. 1 mg/l in case of EC50 between 1 and 10 mg/l), (iii) NOEC or EC10 was used if EC50 was not available, and (iv) toxicity estimates for the a.s.s
As part of the ENRIECO project, we evaluated existing human biomonitoring data for these substances in European birth cohorts and develop recommendations for more harmonized methods that will enable combination and comparison of cohort data in the future.
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