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This study can be used as a promising strategy that efficiently maximize utilization of currently limited human brain transcriptome data for the extensive identification of potentially valuable molecular basis for neurological dysfunction commonly in multiple brain diseases.
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The pre-clinical data provided strong rationale for the extensive medicinal chemistry campaigns that ensued in multiple companies to develop brain-penetrant ligands for the 5-HT6 receptors.
Detailed hospital admission and discharge records provide data for an extensive body of literature examining the relationship between hospital admissions and air pollution.
The British situation provides a good basis for a case study, because of its relevance for disease management, but also for the extensive data on the host species populations.
We suggest instead that to solve the complex riddle of AD, theoretical models must expand beyond Aβ as the central cause of dysfunction, instead including Aβ in a wider theory that accounts for the extensive data and advances in neuroscience that have accumulated over the last decade.
The authors thank the medical doctors and nurses of the Public Health Service Amsterdam for their assistance in subject inclusion and data collection, in particular Gijs Baaten for the extensive work in this study; Floor Elfrink and Bart Maertzdorf for facilitating data management; Sally H. Ebeling for editorial review.
Much effort can be saved from obtaining detailed data for an extensive but proper model, but a less detailed model might not describe the network behavior with sufficient accuracy.
Here we combine high-resolution land cover data for the Minnesota River basin with spatially extensive repeat water sampling data.
We therefore examined the HapMap data for the Yoruba to obtain more extensive genomic data from people living in a nearby area of West Africa.
Although past studies have generated extensive data for the genetics of the MHC resulting in important contributions to medicine [ 2- 4] further studies are necessary to improve our understanding of the causes of such diseases.
Molecular data for the survey provide the most extensive assessment of Hawaiian red algal diversity and, in combination with the morphological/anatomical and distributional data collected as part of the project, provide a solid baseline data set for future studies of the flora.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com