Another example of a mouse atlas that provides gene expression data for the mouse brain is the GENSAT brain atlas.
They are, together with Ins, important for the separation between data from the brain and the spinal cord.
For our analysis, we downloaded the gene expression data for caudate, the brain region mostly affected in HD and sorted them based on the statistical significance (p < 0.05).
"When we started in 2015 and talked about a data link for the brain, no one realized how close we were to commercialization," says Angle.
The downside, which effectively decided the Grand Tour in the very first round when Hikaru Nakamura blundered against Wesley So, is that there is much more data for the human brain to recall at the board, leading to mixing up variations or making moves in the wrong order.
Gene expression data for the mouse brain is also available from EMAGE.
In situ hybridization data for the mouse brain in the Allen Brain Atlas (http://www.brain-map.org) also show intense ATP1A3 mRNA reactivity in cell somas in cerebellum, dentate nucleus, red nucleus, inferior olivary nucleus, and other regions of interest, supporting the possibility that pathology is intrinsic to cells that express the mutated enzyme.
Ouyang A, Jeon T, Sunkin SM, Pletikos M, Sedmak G, Sestan N, Lein ES, Huang H (2014) Spatial mapping of structural and connectional imaging data for the developing human brain with diffusion tensor imaging.
Although, plenty of gene expression data for the developing mouse brain are publicly accessible, interaction databases such as STRING (23), IntAct (24) or BioGRID (25) do not provide high spatial resolution on a developmental time scale.
Next month, tests will begin in monkeys of a new implant for piping data into the brain that is designed to avoid that problem.
