Phase II established and evaluated the database of chemical genetic toxicity data for its relevance to identifying human health hazards.
Because constraints-based models are often underdetermined they may provide multiple mathematically-equivalent solutions to a specific question – these equivalent solutions must be assessed with experimental data for biological relevance [ 18].
The proxy data for the relevance of the industrial sector seem to follow similar trends as the differences in CO2 emissions between Czechoslovakia and Austria the development of the industrial sector thus seems to correlate with the differences in CO2 emissions between the two countries in the observed time period.
Data were reviewed for relevance to OTS and then evaluated against criteria that included significant OTS outcomes and findings.
Small molecule-associated data with relevance for drug discovery include, first and foremost, chemical structure, compound activity, biological screening, and pharmacological data, which rapidly grow.
The steps in this approach involve assembling the relevant data (either positive or negative), evaluating these data for quality and relevance, and integrating the different points of evidence to support conclusions concerning specific properties of the substance.
Due to the lack of available human data for comparison, the relevance of using the fetal calf skull as a model for human infants and young children remains inconclusive.
Cristofanilli et al. first demonstrated convincing data for the prognostic relevance of CTCs in breast cancer patients though use of CellSearch technology.
As long as experimental data for a functional relevance of RIs are missing, we note that RIs qualify as mediators for a splicing-dependent mechanism of gene expression regulation, based on structure as well as on statistical association with functional categories (see below).
Qualitatively, data were also evaluated for relevance for human exposures, with consideration for the route of exposure and outcome studied.
A decision-tree model, with data and assumptions adapted for relevance to China, was developed to project the health outcomes of PCV-7 vaccination (compared with no vaccination) over a 5-year period as well as a lifetime.
