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We have chosen ACE, as a particular interesting example, because for this target we observed the highest ΔpROC-AUC ΔpROC-AUCe between MOE and Maestro prepared data for GOLD and a large ΔpROC-AUC prep for Glide.
Figure 1 compares the generalised Gibbs-Thomson relation against experimental data for gold nanoparticles in the range 2-12 nm, see [12]. Figure 1 Melt temperature versus radius of gold nanoparticles.
In Abundance, I wrote about my friend Rob McEwen, chairman of Goldcorp, who literally mined his data for gold bullion.
For reference, the same table also includes the data for gold nanoshells filled with silica.
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Thus, our findings are in a good agreement with reported surface plasmon resonance data for gold-silver alloy nanoshells when the absorption was tuned from 430 to 780 nm.
Therefore, instead of considering individual cell conditions, we merged all the context-specific targets of a TF for our prediction set (the union of the intersection parts in Figure 2a), and merged multiple ChIP-seq or ChIP-chip data for gold-standard targets of a TF.
Our observation is consistent with data reported for gold nanoshells deposited on magnetite cores by others [62 64], as well as with ICP-AES results (Table 1) which indicated a molar ratio of Au Ag = 0.4 (theoretical ratio 1 1) and 5.3, respectively (theoretical ratio 5 1).
The primary source of data for our gold standard network, which we label GSN, regulating cell fate decisions in the C. elegans C lineage is [ 14], with additional data curated from the literature (Additional file 1: Table S 1, tabs "Gene interactions" and "Gene interactions – refs").
An outside team had come to examine the data Cobalt assembled for Gold Dust; if the ridge held oil, the scientists concluded, it would likely hold between three billion and six billion barrels of it.
Its efficiency in cheminformatics and QSAR modelling is shown with three use cases: proteomics data for surface-modified gold nanoparticles, nano-metal oxides descriptor data, and molecular descriptors for acute aquatic toxicity data.
Redesigning a challenge can be laborious as it might imply obtaining data for a new gold standard and change assumptions that simplified the underlying biology and favored a good challenge formulation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com